Further characterization ofShigella sonneilive vaccine candidates WRSs2 and WRSs3-plasmid composition, invasion assays and Sereny reactions
نویسندگان
چکیده
منابع مشابه
Shigella sonnei vaccine candidates WRSs2 and WRSs3 are as immunogenic as WRSS1, a clinically tested vaccine candidate, in a primate model of infection.
Shigella causes diarrhea and dysentery through contaminated food and water. Shigella sonnei live vaccine candidates WRSs2 and WRSs3 are attenuated principally by the loss of VirG(IcsA) that prevents bacterial spread within the colonic epithelium. In this respect they are similar to the clinically tested vaccine candidate WRSS1. However, WRSs2 and WRSs3 are further attenuated by loss of senA, se...
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ژورنال
عنوان ژورنال: Gut Microbes
سال: 2011
ISSN: 1949-0976,1949-0984
DOI: 10.4161/gmic.2.4.17042